Overview
Hepatocellular carcinoma needs to be diagnosed earlier. Detecting HCC in its early stage may increase the prognostic 5-year survival rate from less than 5%2 in the case of late stages, to up to 70% for early stages.3 HCC is often not symptomatic until the later stages, at which the 5-year survival rate can be less than 5%, meaning growing numbers of patients with liver cancer are progressing silently towards a lower chance of survival.2
Ultrasound and AFP testing are the current standard of care with early detection sensitivity of respectively 45% for ultrasound4 and 63% for Ultrasound + AFP4, but we need to provide a solution with more precision.
According to the study by Farvardin, patients face barriers to HCC surveillance, including challenges with scheduling, high costs of tests, uncertainty about where to obtain ultrasounds and transportation difficulties.5 These obstacles hinder access to vital care for at-risk patients.
52% of patients have good compliance and are able to follow guidelines or expert suggestion for liver cancer surveillance.6
Cost-effectiveness represents a barrier to the implementation of HCC surveillance programs, especially considering the emerging shift from viral to metabolic etiologies of HCC, leading to an increase of the target population.7
GAAD test to aid in the diagnosis of early and all stage hepatocellular carcinoma (HCC).¹
HCC is the most common form of liver cancer, accounting for nearly 90% of the liver cases and it is also the third leading cause of death.2,8,9
HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis.10 In fact, in high-risk groups, biannual screening has decreased HCC mortality by 37%.11
In one year we can only test a few thousand people, however, over 10,000 people are at risk of liver cancer. Due to ultrasound capacity limitations, patients may have to wait for months or even a year for a scan.
GAAD is an in vitro diagnostic multivariate index assay utilized by clinicians to assist in the diagnosis of HCC, by combining in an algorithm the quantitative measurements of Elecsys AFP assay and Elecsys PIVKA II assay together with gender and age. GAAD must be interpreted in conjunction with other diagnostic findings and clinical information in accordance with standards clinical management guidelines.1
Both biomarkers automatically available via navify Algorithm Suite.1
Clinical performance demonstrated in a multicenter evaluation study.13
Superior performance to AFP alone.13
1st diagnostic multivariate index assay from Roche - aid in diagnostic for HCC.1
Prof. Dr. Ralf Lichtinghagen | Laboratory Director at the University Hospital of Hannover
Benefits
Discover the transformative benefits of the GAAD algorithm, designed to deliver an easy-to-understand and clinically validated risk score for early and all stages HCC detection. Directly integrating into the existing clinician's (electronic health records) workflows via navify Algorithm Suite, GAAD enables an automated process that supports healthcare professionals to act swiftly and effectively.
Easy-to-understand and accurate risk score, a cut-off that is clinically validated.1,13,14,15
GAAD has a specificity of 97.3% and a sensitivity of 70.1% for early-stage HCC detection and 83.1% sensitivity for all stages.13
Amplify the signs of early-stage HCC, helping healthcare professionals in more effective clinical decisions.
GAAD directly integrates into the existing workflow via navify Algorithm Suite, enabling a fully automated workflow.
Elevate your HCC detection capabilities with our evidence-based digital solution.The combination of GAAD and ultrasound achieves a remarkable 92.5% sensitivity for all stages of hepatocellular carcinoma.14 With GAADs high specificity of 94.6% and sensitivity of 73.1% and 77.4% for early-stage and all stages,14 you can enhance early-stage diagnosis seamlessly within your current workflow using navify Algorithm Suite. Download our brochure to explore how GAAD can transform your clinical practice.
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GAAD is a CE-marked (NB 0123)* algorithm integrated into navify Algorithm Suite. The cloud-based platform enables direct integration of the GAAD algorithm into the existing workflow. Watch the video.
*Not available in the US. Local registration status varies according to local regions. Please confirm the registration status of GAAD with your local Roche representative.
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